Tamizhazhagan, V.Pugazhendy, K.Sakthidasan, VJayanthicSawicka, BarbaraHumphrey, AgeviC, VasanthKasinathan, MM Baranitharan Ph D, Dr2024-02-052024-02-052017-05-30amizhazhagan V, Pugazhendy K, Sakthidasan V, Jayanthi C.W The Toxicity Effect of Monocrotophos 36% E.C on the Biochemical Change in Catla Catla (Hamilton, 1882). Glob J Pharmaceu Sci 2(2) : 555585 (2017)http://dx.doi.org/10.21276/ijcpahttps://repository.nrf.go.ke/handle/123456789/550This study was undertaken to find out the Catla catlafresh water fish biochemical changes in the fish muscles, liver, and kidney. Toxicity were calculated probit analysis, The total carbohydrate contented was estimated by the technique of Roe , Protein was estimated by Lowry method and total lipids were estimated by the method of floch methods. The results shown on total carbohydrate level in muscle 6.43 mg/g after treatment 2.70 mg/g, liver carbohydrate control 17.55mg/g after treatment 16.10 mg/g changes accrued 7.41 %and kidney carbohydrate control 1.44mg/g after treatment 0.53mg/g was gradually decreased. Then total protein in muscles23.20 mg/g after sublethal concentration at 96 hours treated 17.80mg/g decreased and liver protein 23.12mg/g treated fish 19.40 mg/g changes accrued 13.58% kidney protein level 9.60 mg/g after treatment in sublethal concentration in 96 hours 6.24 mg /g were decreased and Total lipid level are in muscles 1.78mg/g after 96 hours 0.89mg/g liver lipid 7.10 mg/g after treatment 4.35mg/g then kidney 2.09mg/g 0.92 mg/g simultaneous gradually decreased muscles, liver and kidney. The Monocrotophos affects not only fishes but also organisms in the food chain through the procedure of expenditure of one by the other those human begins affected various genetic disorders absolutely insecticides.enMasinde Muliro University of Science and TechnologyArticle