Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives

Samuel N. Nyamu, Lucy Ombaka, Eric Masika, and Margaret Ng’ang’a

Publication:
Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives

dc.contributor.author	Samuel N. Nyamu, Lucy Ombaka, Eric Masika, and Margaret Ng’ang’a
dc.date.accessioned	2025-11-14T06:31:18Z
dc.date.issued	2018-03-19
dc.description.abstract	Microbial pathogens have increasingly shown multidrug resistance posing a serious threat to the public health. Advances in technology are opening novel avenues for discovery of compounds that will mitigate the ever-increasing drug-resistant microbes. Use of photodynamic photosensitizer is one of the promising alternative approaches since they ofer low risk of bacteria resistance as they use generated reactive oxygen species to kill the microbes. Phthalocyanine (Pc) is one such photosensitizer which has already shown promising antimicrobial photodynamic therapeutic properties. Previous studies have shown efectiveness of the Pc against Gram-positive bacteria. However, its efectiveness toward Gram-negative bacteria is limited by the impermeability of the bacteria’s outer membrane which is made up of lipopolysaccharides layer. Te efectiveness of this photosensitizer is determined by its photophysical and photochemical properties such as singlet/triplet lifetimes, singlet oxygen quantum yields, and fuorescence quantum yield. Terefore, this review focuses on the recent signifcance advances on designing Pc that have this improved property by either conjugating with nanoparticles, quantum dots, functional groups in peripheral position, considering efect of cationic charge, and its position on the macrocycle.
dc.description.sponsorship	NRF
dc.identifier.uri	https://doi.org/10.1155/2018/2598062
dc.identifier.uri	https://repository.nrf.go.ke/handle/123456789/1504
dc.language.iso	en
dc.publisher	Hindawi Advances in Chemistry
dc.relation.ispartofseries	Volume 2018, Article ID 2598062, 8 pages
dc.title	Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives
dc.type	Article
dspace.entity.type	Publication