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Genetic diversity and population structure of Plasmodium falciparum in Kenyan–Ugandan border areas

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dc.contributor.authorNderu, David
dc.contributor.authorKimani, Francis
dc.contributor.authorKaranja, Evaline
dc.contributor.authorThiong'o, Kelvin
dc.contributor.authorAkinyi, Maureen
dc.contributor.authorToo, Edwin
dc.contributor.authorChege, William
dc.contributor.authorNambati, Eva
dc.contributor.authorWangai, Laura N.
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2024-06-20T10:26:33Z
dc.date.issued2019
dc.description.abstractKenya has, in the last decade, made tremendous progress in the fight against malaria. Nevertheless, continued surveillance of the genetic diversity and population structure of Plasmodium falciparum is required to refine malaria control and to adapt and improve elimination strategies. Twelve neutral microsatellite loci were genotyped in 201 P. falciparum isolates obtained from the Kenyan–Ugandan border (Busia) and from two inland malaria-endemic sites situated in western (Nyando) and coastal (Msambweni) Kenya. Analyses were done to assess the genetic diversity (allelic richness and expected heterozygosity, [He]), multilocus linkage disequilibrium () and population structure. A similarly high degree of genetic diversity was observed among the three parasite populations surveyed (mean He = 0.76; P > 0.05). Except in Msambweni, random association of microsatellite loci was observed, indicating high parasite out-breeding. Low to moderate genetic structure (FST = 0.022–0.076; P < 0.0001) was observed with only 5% variance in allele frequencies observed among the populations. This study shows that the genetic diversity of P. falciparum populations at the Kenyan–Ugandan border is comparable to the parasite populations from inland Kenya. In addition, high genetic diversity, panmixia and weak population structure in this study highlight the fitness of Kenyan P. falciparum populations to successfully withstand malaria control interventions.
dc.description.sponsorshipInternational Society for Infectious Diseases (ISID)
dc.identifier.citationNderu D, Kimani F, Karanja E, Thiong'o K, Akinyi M, Too E, Chege W, Nambati E, Wangai LN, Meyer CG, Velavan TP. Genetic diversity and population structure of Plasmodium falciparum in Kenyan-Ugandan border areas. Trop Med Int Health. 2019 May;24(5):647-656. doi: 10.1111/tmi.13223. Epub 2019 Mar 18. PMID: 30816614.
dc.identifier.urihttps://doi.org/10.1111/tmi.13223
dc.identifier.urihttps://repository.nrf.go.ke/handle/123456789/855
dc.language.isoen
dc.publisherwiley publishers
dc.subjectPlasmodium falciparum
dc.subjectmicrosatellites
dc.subjectgenetic diversity
dc.subjectpopulation structure
dc.subjectmalaria
dc.subjectKenya
dc.titleGenetic diversity and population structure of Plasmodium falciparum in Kenyan–Ugandan border areas
dc.typeArticle
dspace.entity.typePublication

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