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Immunological Responses to Pneumococcal Conjugate Vaccine and Intestinal Nematodes Infestation in Children

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dc.contributor.authorAllan, Lynda A.
dc.contributor.authorYole, Dorcas S.
dc.contributor.authorMbai, Fiona N.
dc.date.accessioned2024-07-03T08:52:54Z
dc.date.issued2017
dc.description.abstractPneumonia is among the leading killer diseases of children under five years in Kenya. The most common bacteriological cause of severe and fatal pneumonia is Streptococcus pneumonia (S. pneumonia). S. pneumoniae is usually carried in the nasopharynx of healthy people, but occasionally leads to invasive pneumococcal diseases (IPDs), such as meningitis, pneumonia, otitis, sinusitis and bacteremia. Annually, World Health Organization (WHO) estimates the occurrence of one and a half million of deaths in children under five years, mainly in poor countries.In Kenya, A 10-valent Pneumococcal Conjugate Vaccine (PCV10) introduction into routine immunization schedule has resulted in reduction of the incidence of Invasive Pneumococcal diseases (IPD). However, there is a need to systematically evaluate the confounding factors that limit vaccine efficacy. A common although often overlooked confounding factor in the PCV10 vaccination efficacy is the presence of gastrointestinal nematode parasites in humans, particularly in children living in slums. Here the intestinal nematodes are prevalent and their effects result in an immuno-compromised state. We review the possibility of concurrent intestinal nematode infestation altering PCV10-induced responses in children and the need to devise efficacious treatment strategies
dc.description.sponsorshipNACOSTI
dc.identifier.citationAllan, L., Yole, D., & Mbai, F. (2017). Immunological Responses to Pneumococcal Conjugate Vaccine and Intestinal Nematodes Infestation in Children. International Journal of TROPICAL DISEASE & Health, 26(4), 1-12.
dc.identifier.issn2278-1005
dc.identifier.urihttps://journalijtdh.com/index.php/IJTDH/article/view/102/203
dc.identifier.urihttps://repository.nrf.go.ke/handle/123456789/1088
dc.language.isoen
dc.publisherAllan et al.
dc.subjectIntestinal nematodes
dc.subjectchild health
dc.subjectpneumonia
dc.subjectvaccines
dc.subjectimmune responses
dc.subjectinfectious diseases
dc.titleImmunological Responses to Pneumococcal Conjugate Vaccine and Intestinal Nematodes Infestation in Children
dc.typeArticle
dspace.entity.typePublication

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