Publication:
Antibacterial Activities Investigation of Leucas calostachys Root Extracts

dc.contributor.authorNicholas K. Kimutai, Philip A. Ogutu and Charles Mutai
dc.date.accessioned2025-05-19T09:41:32Z
dc.date.issued2021
dc.description.abstractBackground and Objective: Traditional healers have long used plants to treat bacterial infections caused by resistant bacteria. Hence, there is an increased interest in the ethnopharmacological approach to identify new novel compounds from plants to treat these infections. The objective of this study, therefore, was to test successive extracts and their fractions. Materials and Methods: The roots of Leucas calostachys were obtained, dried and ground. The total methanol extract was obtained and screen for antibacterial activities. Successive extracts were extracted using four different solvents hexane, dichloromethane, ethyl acetate and methanol. The bioactive solvent extracts were fractionated. Successive extracts and fractions were then screened for antibacterial activities against ten pathogenic bacteria in vitro using the disk diffusion method. Results: The results indicated the solvent extracts and fractions were active against both gram-negative and gram-positive bacteria with the lowest MIC value of 3.15 mg mLG1 obtained from total methanol extract against methicillin-resistant Staphylococcus aureus. Conclusion: This demonstrated that hexane extracts and fractions could be helpful in the management of resistant bacterial infections. This work is the first attempt to fractionate and test fractions of L. calostachys, which can be used for the development of phytomedicine
dc.description.sponsorshipNRF
dc.identifier.citationN.K. Kimutai, P.A. Ogutu and C. Mutai, 2021. Antibacterial activities investigation of Leucas calostachys root extracts. Asian J. Plant Sci., 20: 470-476.
dc.identifier.uriISSN 1682-3974 DOI: 10.3923/ajps.2021.470.476
dc.identifier.urihttps://repository.nrf.go.ke/handle/123456789/1400
dc.language.isoen
dc.publisherCrossMark
dc.titleAntibacterial Activities Investigation of Leucas calostachys Root Extracts
dc.title.alternativeAsian Journal of Plant Sciences
dc.typeArticle
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
470-476 - Copy.pdf
Size:
570.36 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description: