Publication: Antimicrobial Photodynamic Activity of Phthalocyanine Derivatives
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2018-03-19
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Hindawi Advances in Chemistry
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Abstract
Microbial pathogens have increasingly shown multidrug resistance posing a serious threat to the public health. Advances in
technology are opening novel avenues for discovery of compounds that will mitigate the ever-increasing drug-resistant microbes.
Use of photodynamic photosensitizer is one of the promising alternative approaches since they ofer low risk of bacteria resistance
as they use generated reactive oxygen species to kill the microbes. Phthalocyanine (Pc) is one such photosensitizer which has
already shown promising antimicrobial photodynamic therapeutic properties. Previous studies have shown efectiveness of the Pc
against Gram-positive bacteria. However, its efectiveness toward Gram-negative bacteria is limited by the impermeability of the
bacteria’s outer membrane which is made up of lipopolysaccharides layer. Te efectiveness of this photosensitizer is determined by
its photophysical and photochemical properties such as singlet/triplet lifetimes, singlet oxygen quantum yields, and fuorescence
quantum yield. Terefore, this review focuses on the recent signifcance advances on designing Pc that have this improved property
by either conjugating with nanoparticles, quantum dots, functional groups in peripheral position, considering efect of cationic
charge, and its position on the macrocycle.